抗原受体信号对B细胞命运的调控。

Regulation of B-cell fate by antigen-receptor signals.

作者信息

Niiro Hiroaki, Clark Edward A

机构信息

Department of Microbiology, University of Washington, Seattle, Washington 98195, USA.

出版信息

Nat Rev Immunol. 2002 Dec;2(12):945-56. doi: 10.1038/nri955.

DOI:10.1038/nri955

PMID:12461567

Abstract

Recent evidence indicates that B cells are instructed continuously by B-cell receptor (BCR) signals to make crucial cell-fate decisions at several checkpoints during their development. Targeted disruption of BCR signalling components leads to distinct blocks in B-cell maturation, which indicates that key kinases and adaptors fine-tune BCR signalling to direct appropriate cell fates. Recent progress in unravelling the molecular mechanisms of the BCR signalling pathways has helped to clarify how BCR signals regulate the proliferation, survival and apoptosis of developing B cells.

摘要

最近的证据表明，B细胞在其发育过程中的几个检查点会持续受到B细胞受体（BCR）信号的指导，从而做出关键的细胞命运决定。对BCR信号传导成分的靶向破坏会导致B细胞成熟过程中出现明显的阻滞，这表明关键激酶和衔接蛋白会微调BCR信号，以引导适当的细胞命运。在揭示BCR信号通路分子机制方面的最新进展，有助于阐明BCR信号如何调节发育中B细胞的增殖、存活和凋亡。