往昔重现：凋亡细胞的清除调节免疫反应。

A blast from the past: clearance of apoptotic cells regulates immune responses.

作者信息

Savill John, Dransfield Ian, Gregory Chris, Haslett Chris

机构信息

MRC/University of Edinburgh Centre for Inflammation Research, Department of Clinical & Surgical Sciences (Internal Medicine), Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, UK.

出版信息

Nat Rev Immunol. 2002 Dec;2(12):965-75. doi: 10.1038/nri957.

DOI:10.1038/nri957

PMID:12461569

Abstract

Apoptosis, which is a programmed and physiological form of cell death, is known to shape the immune system by regulating populations of effector lymphocytes. However, the binding and ingestion of dying cells by monocytes/macrophages and dendritic cells can also influence immune responses markedly by enhancing or suppressing inflammation. Therefore, dead cells, which are a reflection of an organism's immediate past, can control its immunological future.

摘要

细胞凋亡是一种程序性的生理性细胞死亡形式，已知它通过调节效应淋巴细胞群体来塑造免疫系统。然而，单核细胞/巨噬细胞和树突状细胞对垂死细胞的结合和吞噬也可通过增强或抑制炎症反应，显著影响免疫应答。因此，作为生物体近期状态反映的死亡细胞，能够掌控其免疫方面的未来。