生物系统中依赖于峰电位时间的突触可塑性。

Spike timing dependent synaptic plasticity in biological systems.

作者信息

Roberts Patrick D, Bell Curtis C

机构信息

Neurological Sciences Institute, Oregon Health & Science University, 505 N.W. 185th Avenue, Beaverton, OR 97006, USA.

出版信息

Biol Cybern. 2002 Dec;87(5-6):392-403. doi: 10.1007/s00422-002-0361-y.

DOI:10.1007/s00422-002-0361-y

PMID:12461629

Abstract

Association of a presynaptic spike with a postsynaptic spike can lead to changes in synaptic efficacy that are highly dependent on the relative timing of the pre- and postsynaptic spikes. Different synapses show varying forms of such spike-timing dependent learning rules. This review describes these different rules, the cellular mechanisms that may be responsible for them, and the computational consequences of these rules for information processing and storage in the nervous system.

摘要

突触前尖峰与突触后尖峰的关联可导致突触效能的变化，这种变化高度依赖于突触前和突触后尖峰的相对时间。不同的突触表现出这种尖峰时间依赖性学习规则的不同形式。本综述描述了这些不同的规则、可能导致这些规则的细胞机制，以及这些规则对神经系统中信息处理和存储的计算结果。