Açil Y, Springer I N G, Prasse J G, Hedderich J, Jepsen S
Department of Oral and Maxillofacial Surgery, University of Kiel, Arnold-Hellerstrasse 16, 24105 Kiel, Germany.
Int J Legal Med. 2002 Dec;116(6):340-3. doi: 10.1007/s00414-002-0333-8. Epub 2002 Oct 1.
Lysylpyridinoline (LP) and hydroxylysylpyridinoline (HP) are collagen cross-link residues. HP is present in most tissues, whereas LP is specific for bone and dentin. Based on the current literature there are certain indications that measurement of the concentrations of HP and LP in dentin may be a valuable tool to determine the individual age. The purpose of this investigation was to assess if the concentrations of LP and HP in dentin increase during lifetime. We have investigated 173 molars from 173 individuals (2 through 78 years of age, 31 primary and 142 secondary teeth) in the course of the present study. Levels of LP and HP were measured by HPLC and fluorescence detection. The results show that dentinal concentrations of HP and LP did not increase with age and varied between individuals of the same age and that determination of dentinal concentrations of HP and LP cannot be used to determine the individual age.
赖氨酰吡啶啉（LP）和羟赖氨酰吡啶啉（HP）是胶原蛋白交联残基。HP存在于大多数组织中，而LP则是骨骼和牙本质所特有的。基于当前文献，有某些迹象表明，测量牙本质中HP和LP的浓度可能是确定个体年龄的一种有价值的工具。本研究的目的是评估牙本质中LP和HP的浓度在一生中是否会增加。在本研究过程中，我们调查了173名个体（年龄在2至78岁之间，31颗乳牙和142颗恒牙）的173颗磨牙。通过高效液相色谱法（HPLC）和荧光检测法测量LP和HP的水平。结果表明，牙本质中HP和LP的浓度并不随年龄增加，且在同一年龄的个体之间存在差异，因此，测定牙本质中HP和LP的浓度不能用于确定个体年龄。
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