Springer I N G, Terheyden H, Suhr M A A, Warnke P, Dunsche A, Tiemann M, Açil Y
Department of Oral and Maxillofacial Surgery, University of Kiel, Arnold-Hellerstr. 16, D-24105 Kiel, Germany.
Br J Cancer. 2003 Nov 3;89(9):1722-8. doi: 10.1038/sj.bjc.6601325.
The presence of an oral squamous cell carcinoma (OSCC) may be associated with increased urinary excretion of the markers of collagen degradation, hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP). We investigated the possibility of these markers predicting the presence of active disease. Patients from a current study on HP and LP were included as follows: Group 1a (OSCC with confirmed mandibular bony infiltration, n=12), group 1b (group 1a patients >6 months after successful treatment), group 2a (OSCC without evidence of mandibular bone infiltration, n=8), group 2b (group 2a patients >6 months after successful treatment), group 3a (recurrent OSCC, n=8), group 3b (group 3a patients >6 weeks later, symptoms unchanged) and group 4 (control group, n=74). Tissue samples from tumour tissue and adjacent healthy mucosa were additionally investigated for HP and LP concentrations (n=8). The decrease in the urinary concentrations of HP and LP was statistically significant between groups 1a and 1b (P<0.001 for HP and LP), but not between groups 2a and 2b (P=0.07 for HP and LP), while values in groups 1b and 2b were within the normal range. When comparing groups 3a and 3b, a significant increase was observed for LP (P=0.050), but not HP (P=0.208). In conclusion, successful treatment of OSCC with bony involvement may be associated with a reduction of urinary HP and LP, whereas ongoing disease may result in an increase of LP. HP and LP may both be useful markers of tumour progression in patients with OSCC.
口腔鳞状细胞癌（OSCC）的存在可能与胶原蛋白降解标志物——羟赖氨酰吡啶啉（HP）和赖氨酰吡啶啉（LP）的尿排泄增加有关。我们研究了这些标志物预测活动性疾病存在的可能性。当前一项关于HP和LP的研究中的患者纳入情况如下：1a组（确诊有下颌骨浸润的OSCC，n = 12），1b组（1a组患者成功治疗6个月后），2a组（无下颌骨浸润证据的OSCC，n = 8），2b组（2a组患者成功治疗6个月后），3a组（复发性OSCC，n = 8），3b组（3a组患者6周后，症状未改变）和4组（对照组，n = 74）。另外还对肿瘤组织和相邻健康黏膜的组织样本进行了HP和LP浓度检测（n = 8）。HP和LP的尿浓度在1a组和1b组之间有统计学显著下降（HP和LP均P<0.001），但在2a组和2b组之间无显著下降（HP和LP均P = 0.07），而1b组和2b组的值在正常范围内。比较3a组和3b组时，LP有显著升高（P = 0.050），但HP无显著升高（P = 0.208）。总之，成功治疗有骨受累的OSCC可能与尿中HP和LP的减少有关，而疾病持续存在可能导致LP升高。HP和LP可能都是OSCC患者肿瘤进展的有用标志物。
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