Strengers P F W, Drenth J C
Acta Anaesthesiol Belg. 2002;53(3):183-6.
In the treatment of reversal of oral anticoagulant therapy, a number of treatment modalities is available and depends on the severity of the clinical situation and the degree of the coagulopathy. FFP and PPSB (PCC) are commonly used in the treatment and/or in combination with cessation of oral anticoagulant therapy and administration of Vitamin K. The double viral inactivated plasma product PPSB-SD is the first choice treatment in this indication because of the relatively constant, high concentrated level of the Vitamin K dependent coagulation factors II, VII, IX and X, compared to FFP.
在口服抗凝治疗逆转的处理中，有多种治疗方式可供选择，这取决于临床情况的严重程度和凝血病的程度。新鲜冰冻血浆（FFP）和凝血酶原复合物（PCC，PPSB）常用于治疗和/或与停用口服抗凝治疗及给予维生素K联合使用。双病毒灭活血浆制品PPSB-SD是该适应证的首选治疗方法，因为与FFP相比，其维生素K依赖凝血因子II、VII、IX和X的水平相对恒定且浓度较高。
