Beck P, Arnett D M, Alsever R N, Eaton R P
Metabolism. 1976 Jan;25(1):23-31. doi: 10.1016/0026-0495(76)90156-6.
The effect of contraceptive steroids on aminogenic glucagon secretion was studied in six insulin-dependent diabetic women. After 2 wk treatment with combined mestranol (80 mug) plus norethindrone (1 mg) daily, the mean peak plasma glucagon response to arginine infusion was suppressed to one-fourth of control levels. This was associated with a small but significant decrease in mean basal plasma cholesterol concentrations. There were no changes in basal plasma triglyceride, free fatty acid, glucose, insulin, or alpha-amino nitrogen concentrations or in daily insulin requirements during mestranol plus norethindrone treatment. These results confirm previous reports of no consistent changes in the insulin requirements of insulin-dependent diabetic women using contraceptive steroids and suggest that these women may not experience dramatic changes in their lipid metabolism during contraceptive therapy.
在六名胰岛素依赖型糖尿病女性中研究了避孕类固醇对氨基生成性胰高血糖素分泌的影响。在用炔雌醇甲醚（80微克）加炔诺酮（1毫克）每日联合治疗2周后，精氨酸输注后血浆胰高血糖素的平均峰值反应被抑制至对照水平的四分之一。这与平均基础血浆胆固醇浓度的小幅但显著下降有关。在炔雌醇甲醚加炔诺酮治疗期间，基础血浆甘油三酯、游离脂肪酸、葡萄糖、胰岛素或α-氨基氮浓度以及每日胰岛素需求量均无变化。这些结果证实了先前关于使用避孕类固醇的胰岛素依赖型糖尿病女性胰岛素需求量无一致变化的报道，并表明这些女性在避孕治疗期间其脂质代谢可能不会发生显著变化。
