甲状腺激素和9-顺式视黄酸对垂体前叶促甲状腺激素的调节。
The regulation of the thyroid-stimulating hormone of the anterior pituitary gland by thyroid hormone and by 9-cis-retinoic acid.
作者信息
Wolf George
机构信息
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720-3104, USA.
出版信息
Nutr Rev. 2002 Nov;60(11):374-7. doi: 10.1301/00296640260385919.
PMID:12462521
Abstract
Thyroid-stimulating hormone, TSH, of the anterior pituitary gland is regulated by the binding of the thyroid hormone-activated thyroid receptor to the TSH gene at the same time as the binding of the 9-cis-retinoic acid-activated retinoid X receptor to the same gene. Both interactions, separately or simultaneously, can suppress and thus regulate the expression of the TSH gene.
摘要
腺垂体分泌的促甲状腺激素（TSH）受甲状腺激素激活的甲状腺受体与TSH基因结合的调控，同时9-顺式视黄酸激活的视黄酸X受体也与同一基因结合。这两种相互作用单独或同时发生，均可抑制并由此调控TSH基因的表达。
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