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关于高剂量甲状腺激素抑制促甲状腺激素的时间进程。

On the time course of thyrotropin suppression by high doses of thyroid hormones.

作者信息

Hüfner M, Gless K H

出版信息

Experientia. 1976 May 15;32(5):655-7. doi: 10.1007/BF01990218.

DOI:10.1007/BF01990218
PMID:819291
Abstract

Basal and stimulated TSH decreased progressively. Basal TSH was suppressed below the detection limit of 0.4 muU/ml after 74 h in 2 of the T3 and all of the T4 treated individuals. At this time in both groups 3 individuals could be significantly stimulated by TRH (abour 5% of the pretreatment stimulation). There was no significant difference in the time course of suppression obtained by T3 or T4 through plasma T3 levels in the T4 treated group were considerably lower.

摘要

基础促甲状腺激素(TSH)和刺激后的TSH逐渐下降。在T3治疗的2名个体以及所有T4治疗的个体中,74小时后基础TSH被抑制至低于0.4 μU/ml的检测限。此时,两组中均有3名个体可被促甲状腺激素释放激素(TRH)显著刺激(约为预处理刺激的5%)。T3或T4通过血浆T3水平获得的抑制时间进程没有显著差异,T4治疗组中的血浆T3水平要低得多。

相似文献

1
On the time course of thyrotropin suppression by high doses of thyroid hormones.关于高剂量甲状腺激素抑制促甲状腺激素的时间进程。
Experientia. 1976 May 15;32(5):655-7. doi: 10.1007/BF01990218.
2
Inhibition of thyrotrophin-releasing hormone responsiveness by physiological concentrations of thyroid hormones in the cultured rat pituitary gland.生理浓度的甲状腺激素对培养的大鼠垂体中促甲状腺激素释放激素反应性的抑制作用。
J Endocrinol. 1977 Sep;74(3):405-14. doi: 10.1677/joe.0.0740405.
3
Mathematical model of pituitary thyrotropic function.垂体促甲状腺功能的数学模型
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4
Thyrotropin-releasing hormone and thyroid hormone interactions on thyrotropin secretion in the rat: lack of inhibiting effects of small doses of triiodo-L-thyronine in the hypothyroid rat.促甲状腺激素释放激素与甲状腺激素对大鼠促甲状腺激素分泌的相互作用:小剂量L-三碘甲状腺原氨酸对甲状腺功能减退大鼠无抑制作用
Endocrinology. 1976 Jan;98(1):203-13. doi: 10.1210/endo-98-1-203.
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Studies on the control of thyrotrophin secretion in normal man.
Clin Endocrinol (Oxf). 1976 Sep;5(5):515-20. doi: 10.1111/j.1365-2265.1976.tb01980.x.
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Comparison of inhibitory effects of 3,5,3'-triiodothyronine (T3), thyroxine (T4), 3,3,',5'-triiodothyronine (rT3), and 3,3'-diiodothyronine (T2) on thyrotropin-releasing hormone-induced release of thyrotropin in the rat in vitro.3,5,3'-三碘甲状腺原氨酸(T3)、甲状腺素(T4)、3,3',5'-三碘甲状腺原氨酸(反T3,rT3)和3,3'-二碘甲状腺原氨酸(T2)对大鼠体外促甲状腺激素释放激素诱导的促甲状腺激素释放抑制作用的比较。
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引用本文的文献

1
Plummer's disease: localized thyroid autonomy.普卢默病:局限性甲状腺自主性。
J Endocrinol Invest. 1987 Apr;10(2):207-24. doi: 10.1007/BF03347193.

本文引用的文献

1
[Studies of the radioimmunochemical determination of human thyroid stimulating hormone (H-TSH)].[人促甲状腺激素(H-TSH)放射免疫化学测定的研究]
Z Klin Chem Klin Biochem. 1971 May;9(3):257-65.
2
Radioimmunoassay for triiodothyronine in human serum.
Acta Endocrinol (Copenh). 1973 Mar;72(3):464-74. doi: 10.1530/acta.0.0720464.
3
Inhibition of thyrotropin releasing hormone (TRH) stimulated thyrotropin (TSH) secretion in man by a single oral dose of thyroid hormone.单次口服甲状腺激素对促甲状腺激素释放激素(TRH)刺激的人促甲状腺激素(TSH)分泌的抑制作用。
Horm Metab Res. 1972 Nov;4(6):508. doi: 10.1055/s-0028-1097110.
4
Modulation of pituitary responsiveness to thyrotropin-releasing hormone by triiodothyronine.三碘甲状腺原氨酸对垂体促甲状腺激素释放激素反应性的调节作用。
J Clin Invest. 1973 Jan;52(1):205-9. doi: 10.1172/JCI107166.
5
Inhibition of thyrotropin response to thyrotropin-releasing hormone by small quantities of thyroid hormones.少量甲状腺激素对促甲状腺激素释放激素引起的促甲状腺激素反应的抑制作用。
J Clin Invest. 1972 Aug;51(8):2077-84. doi: 10.1172/JCI107014.
6
Rapid simultaneous radioimmunoassay for triiodothyronine and thyroxine in unextracted serum.未提取血清中三碘甲状腺原氨酸和甲状腺素的快速同步放射免疫测定法。
Biochem Biophys Res Commun. 1972 Mar 24;46(6):2107-13. doi: 10.1016/0006-291x(72)90766-8.
7
A thyroid suppression test using a single dose of L-thyroxine.使用单剂量左旋甲状腺素进行的甲状腺抑制试验。
N Engl J Med. 1970 Aug 20;283(8):402-5. doi: 10.1056/NEJM197008202830805.
8
Thyrotrophin-releasing hormone as a thyroid-function test.促甲状腺激素释放激素作为一种甲状腺功能测试。
Lancet. 1971 Jul 3;2(7714):10-4. doi: 10.1016/s0140-6736(71)90005-5.
9
Effect of a single oral dose of triiodothyronine on the subsequent response to TRH in normal individuals.单次口服三碘甲状腺原氨酸对正常个体随后促甲状腺激素释放激素反应的影响。
J Clin Endocrinol Metab. 1975 Jan;40(1):157-9. doi: 10.1210/jcem-40-1-157.