Chen Hung-Yin, Lien Yu-Hsin, Huang Hui-Pi
Institute of Veterinary Clinical Science, Veterinary School, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei 100, Taiwan.
Institute of Veterinary Clinical Science, Veterinary School, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei 100, Taiwan; Azu Clinic for Animals, No. 92, Section 1, Kin-Shan South Road, Taipei 100, Taiwan.
Int J Endocrinol. 2016;2016:3814034. doi: 10.1155/2016/3814034. Epub 2016 May 31.
An increased renal resistive index (RI) and albuminuria are markers of target organ damage secondary to systemic hypertension. This study evaluated associations between systemic blood pressure (SBP), renal RI, pulsatility index (PI), and albuminuria in dogs with pituitary-dependent hyperadrenocorticism (PDH). Predictors of overall mortality were investigated. Twenty client-owned dogs with PDH and 20 clinically healthy client-owned dogs as matched controls were included. Incidence rates of systemic hypertension (SBP ≥ 160 mmHg), albuminuria, and increased renal RI (≥ 0.70) and PI (≥ 1.45) in the control group were 5%, 0%, 5%, and 0%, respectively, compared to 35%, 40%, 50%, and 35%, respectively, in the PDH group (P = 0.001, P < 0.001, P < 0.001, and P = 0.001, resp.). No association between systemic hypertension, renal RI, renal PI, and albuminuria was observed. PDH was the only predictor of albuminuria and increased renal RI. Survival was not affected by increased renal PI, systemic hypertension, or albuminuria. Increased renal RI (≥ 0.70) was the only predictor of overall mortality in dogs with PDH.
肾阻力指数（RI）升高和蛋白尿是系统性高血压继发靶器官损害的标志物。本研究评估了垂体依赖性肾上腺皮质功能亢进症（PDH）犬的系统性血压（SBP）、肾RI、搏动指数（PI）和蛋白尿之间的关联。研究了总体死亡率的预测因素。纳入20只患有PDH的客户拥有犬和20只临床健康的客户拥有犬作为匹配对照。对照组中系统性高血压（SBP≥160 mmHg）、蛋白尿、肾RI升高（≥0.70）和PI升高（≥1.45）的发生率分别为5%、0%、5%和0%，而PDH组分别为35%、40%、50%和35%（分别为P = 0.001、P < 0.001、P < 0.001和P = 0.001）。未观察到系统性高血压、肾RI、肾PI和蛋白尿之间的关联。PDH是蛋白尿和肾RI升高的唯一预测因素。肾PI升高、系统性高血压或蛋白尿均不影响生存率。肾RI升高（≥0.70）是PDH犬总体死亡率的唯一预测因素。
