Watts Steve A, Noble Sara L, Smith Patrick O, Disco Marilyn
Department of Family Medicine, University of Mississippi Medical Center, Jackson 39216, USA.
J Am Board Fam Pract. 2002 Nov-Dec;15(6):489-97.
First-line pharmacotherapies for tobacco use and dependence (namely, nicotine patch, nicotine gum, nicotine inhaler, nicotine nasal spray, and sustained-release bupropion) are safe and have been empirically determined to be efficacious and should always be considered part of a tobacco treatment intervention program unless contraindicated. Studies published subsequent to the literature synthesized in TTUD support previously determined efficacy of first-line pharmacologic medications for treatment of tobacco use and dependence. Further studies will be necessary to define clearly the efficacy and relative safety of combination treatments.
用于烟草使用和依赖的一线药物治疗（即尼古丁贴片、尼古丁口香糖、尼古丁吸入器、尼古丁鼻喷雾剂和缓释安非他酮）是安全的，并且经实证确定是有效的，除非有禁忌，应始终被视为烟草治疗干预计划的一部分。在烟草使用和依赖治疗（TTUD）中综合的文献之后发表的研究支持了先前确定的一线药物治疗烟草使用和依赖的疗效。需要进一步的研究来明确联合治疗的疗效和相对安全性。
