皮蠹科昆虫引起的羊毛工人职业性鼻结膜炎和哮喘
Occupational rhinoconjunctivitis and asthma in a wool worker caused by Dermestidae spp.
作者信息
Brito F Feo, Mur P, Barber D, Lombardero M, Galindo P A, Gómez E, Borja J
机构信息
Section of Allergy, Hospital Complex, Ronda del Carmen, s/n 13002 Ciudad Real, Madrid, Spain.
出版信息
Allergy. 2002 Dec;57(12):1191-4. doi: 10.1034/j.1398-9995.2002.23676.x.
BACKGROUND
The family Dermestidae belongs to the order Coleoptera. Occupational allergy has been described in museum personnel. A 31-year-old male wool worker presenting rhinoconjunctivitis and asthma episodes probably linked to exposure to Dermestidae-infected wool was investigated.
METHODS
Extracts prepared either from insect bodies or from dust from parasitized wool were used for skin prick testing (SPT), conjunctival and bronchial provocation tests and in vitro determinations.
RESULTS
SPT and provocation tests were positive to both extracts. PEFR measurement demonstrated the association between the patient's symptoms and occupational exposure to Dermestidae. Specific IgE to both extracts was detected and immunoblotting revealed several protein bands from 5 to 200 kDa that were reactive to IgE from the patient's serum.
CONCLUSIONS
Dermestidae exposure in wool workers when handling parasitized wool can be a cause of IgE-mediated rhinoconjunctivitis and asthma.
背景
皮蠹科属于鞘翅目。博物馆工作人员中曾有职业性过敏的报道。对一名31岁的男性羊毛工人进行了调查，他出现了 rhinoconjunctivitis 和哮喘发作，可能与接触受皮蠹科感染的羊毛有关。
方法
用昆虫尸体提取物或受寄生羊毛的灰尘提取物进行皮肤点刺试验（SPT）、结膜和支气管激发试验以及体外测定。
结果
两种提取物的SPT和激发试验均呈阳性。呼气峰流速（PEFR）测量表明患者症状与职业性接触皮蠹科之间存在关联。检测到对两种提取物的特异性IgE，免疫印迹显示有几条5至200 kDa的蛋白带与患者血清中的IgE发生反应。
结论
羊毛工人在处理受寄生羊毛时接触皮蠹科可能是IgE介导的 rhinoconjunctivitis 和哮喘的一个原因。
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