Allende Maria Laura, Proia Richard L
Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1821, USA.
Curr Opin Struct Biol. 2002 Oct;12(5):587-92. doi: 10.1016/s0959-440x(02)00376-7.
Gangliosides--glycosphingolipids that contain sialic acid--are concentrated in plasma membrane lipid domains that are specialized for cell signaling. Recent evidence indicates that gangliosides have two different roles in cell signaling. They can act in cis to modulate tyrosine kinase receptor function and in trans as ligands for receptors that facilitate communication between cells. These signaling functions of gangliosides may be potential therapeutic targets in cancer, diabetes and nerve regeneration.
神经节苷脂——含有唾液酸的糖鞘脂——集中于专门用于细胞信号传导的质膜脂质结构域中。最近的证据表明，神经节苷脂在细胞信号传导中具有两种不同的作用。它们可以在顺式作用中调节酪氨酸激酶受体功能，并在反式作用中作为促进细胞间通讯的受体配体。神经节苷脂的这些信号传导功能可能是癌症、糖尿病和神经再生的潜在治疗靶点。
