Rubis Brent A, Danikas Dimitrios, Neumeister Michael, Williams W Geoff, Suchy Hans, Milner Stephen M
Institute for Plastic and Reconstructive Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794-9653, USA.
Burns. 2002 Dec;28(8):752-9. doi: 10.1016/s0305-4179(02)00180-8.
Coverage of large burns may be difficult when skin graft donor sites are limited. This study explored the use of the split-thickness dermal graft (STDG), as an alternative to the standard split-thickness skin graft (STSG). STSGs and STDGs were compared experimentally by their ability to resurface full thickness skin defects in a pig model. Both types of grafts were harvested from the backs of six pigs and placed on full thickness wounds. From the same donor site a 0.012in. thick STSG and another two 0.012in. thick STDGs were harvested. Thus the deep surface of grafts measured 0.012, 0.024 and 0.036in. from the skin surface, respectively. All grafts were placed on 6cmx6cm full thickness wounds. The donor areas healed at 1 week. Epithelialization of the STDGs, was assessed by computerized planimetry, and was 100% at 4 weeks. Graft biopsies revealed that STSGs were significant thinner than STDGs at 1 week (P=0.0422, 0.0135), 2 weeks (P=0.0240) and 4 weeks (P=0.0516, 0.0425). We conclude that STDGs my provide definitive coverage of full thickness skin deficits in a pig wound model.
当皮肤移植供区有限时，大面积烧伤的覆盖可能会很困难。本研究探讨了使用中厚皮片真皮移植物（STDG）作为标准中厚皮片（STSG）的替代方法。通过在猪模型中修复全层皮肤缺损的能力，对STSG和STDG进行了实验比较。两种类型的移植物均取自6头猪的背部，并置于全层伤口上。从同一供区切取一片0.012英寸厚的STSG和另外两片0.012英寸厚的STDG。因此，移植物的深层表面分别距离皮肤表面0.012、0.024和0.036英寸。所有移植物均置于6cm×6cm的全层伤口上。供区在1周时愈合。通过计算机平面测量法评估STDG的上皮化情况，4周时上皮化率为100%。移植物活检显示，在1周（P=0.0422，0.0135）、2周（P=0.0240）和4周（P=0.0516，0.0425）时，STSG明显比STDG薄。我们得出结论，在猪伤口模型中，STDG可能为全层皮肤缺损提供确定性覆盖。
