Lukomskyj Alissa Olga, Rao Nikitha, Yan Lei, Pye Jasmine Sarah, Li Haiyan, Wang Bin, Li Jiao Jiao
Kolling Institute, Faculty of Medicine and Health, University of Sydney, St Leonards, NSW, 2065, Australia.
School of Biomedical Engineering, Faculty of Engineering and IT, University of Technology Sydney, Sydney, NSW, 2007, Australia.
Stem Cell Rev Rep. 2022 Aug;18(6):1926-1955. doi: 10.1007/s12015-022-10341-z. Epub 2022 Feb 12.
Burn wounds are a devastating type of skin injury leading to severe impacts on both patients and the healthcare system. Current treatment methods are far from ideal, driving the need for tissue engineered solutions. Among various approaches, stem cell-based strategies are promising candidates for improving the treatment of burn wounds. A thorough search of the Embase, Medline, Scopus, and Web of Science databases was conducted to retrieve original research studies on stem cell-based tissue engineering treatments tested in preclinical models of burn wounds, published between January 2009 and June 2021. Of the 347 articles retrieved from the initial database search, 33 were eligible for inclusion in this review. The majority of studies used murine models with a xenogeneic graft, while a few used the porcine model. Thermal burn was the most commonly induced injury type, followed by surgical wound, and less commonly radiation burn. Most studies applied stem cell treatment immediately post-burn, with final endpoints ranging from 7 to 90 days. Mesenchymal stromal cells (MSCs) were the most common stem cell type used in the included studies. Stem cells from a variety of sources were used, most commonly from adipose tissue, bone marrow or umbilical cord, in conjunction with an extensive range of biomaterial scaffolds to treat the skin wounds. Overall, the studies showed favourable results of skin wound repair in animal models when stem cell-based tissue engineering treatments were applied, suggesting that such strategies hold promise as an improved therapy for burn wounds.
烧伤创面是一种具有破坏性的皮肤损伤类型，会对患者和医疗系统造成严重影响。目前的治疗方法远非理想，这促使人们寻求组织工程解决方案。在各种方法中，基于干细胞的策略是改善烧伤创面治疗的有前景的候选方案。我们对Embase、Medline、Scopus和Web of Science数据库进行了全面检索，以获取2009年1月至2021年6月间发表的、在烧伤创面临床前模型中测试的基于干细胞的组织工程治疗的原始研究。从最初的数据库搜索中检索到347篇文章，其中33篇符合纳入本综述的条件。大多数研究使用带有异种移植物的小鼠模型，少数使用猪模型。热烧伤是最常见的诱导损伤类型，其次是手术伤口，放射性烧伤较少见。大多数研究在烧伤后立即应用干细胞治疗，最终观察终点为7至90天。间充质基质细胞（MSCs）是纳入研究中最常用的干细胞类型。使用了来自多种来源的干细胞，最常见的是脂肪组织、骨髓或脐带，并结合了广泛的生物材料支架来治疗皮肤伤口。总体而言，研究表明，当应用基于干细胞的组织工程治疗时，动物模型中的皮肤伤口修复取得了良好效果，这表明此类策略有望成为一种改善烧伤创面治疗的方法。
