Onishi Ichiro, Kamata Toru, Hayashi Hironori, Hayashi Yasuo, Minatoya Go, Michiwa Yoshio, Takeda Toshiya, Kanno Masahiro, Takeda Koei
Dept. of Surgery and Gastroenterology, Keiju Medical Center.
Gan To Kagaku Ryoho. 2002 Nov;29(11):1973-6.
We report the case of an 84-year-old woman with vulval extramammary Paget's disease associated with pancreatic cancer who was successfully treated. At first, biweekly low-dose FP (cisplatin 10 mg/body, 5-fluorouracil 250 mg/body) was administered by intravenous infusion. Next, we attempted a regimen of gemcitabine (1,000 mg/body) was administered weekly by intravenous infusion. As a result, the size of the pruritic lesion of the vulva was reduced more than 50%, and the serum level of CA19-9 decreased clearly. These treatments would be a valid option in certain cases of pancreas cancer and extramammary Paget's disease.
我们报告了一例84岁患有外阴部乳腺外佩吉特病并伴有胰腺癌的女性患者，其得到了成功治疗。起初，通过静脉输注每两周给予低剂量FP（顺铂10mg/体，5-氟尿嘧啶250mg/体）。接下来，我们尝试了一种方案，即每周通过静脉输注给予吉西他滨（1000mg/体）。结果，外阴瘙痒性病变的大小缩小了50%以上，血清CA19-9水平明显下降。这些治疗方法在某些胰腺癌和乳腺外佩吉特病的病例中可能是一种有效的选择。
