Discodermolide/软海绵内酯杂合物：合成与生物学评价
Discodermolide/Dictyostatin hybrids: synthesis and biological evaluation.
作者信息
Shin Youseung, Choy Nakyen, Turner Tiffany R, Balachandran Raghavan, Madiraju Charitha, Day Billy W, Curran Dennis P
机构信息
Department of Chemistry, University of Pittsburgh, Pennsylvania 15260, USA.
出版信息
Org Lett. 2002 Dec 12;4(25):4443-6. doi: 10.1021/ol026942l.
PMID:12465908
Abstract
[structure: see text] Two hybrid analogues of discodermolide and dictyostatin (3, 26) have been designed and synthesized. These are the first macrocyclic analogues of discodermolide and biological activities were evaluated and compared with linear discodermolide analogues.
摘要
[结构：见正文] 已设计并合成了两种盘状海绵内酯和双鞭甲藻素（3, 26）的杂合类似物。这些是盘状海绵内酯的首批大环类似物，并对其生物活性进行了评估，并与线性盘状海绵内酯类似物进行了比较。
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