7-脱氧芳基盘状海绵醇类似物的设计、合成及细胞毒性
Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues.
作者信息
Burlingame Mark A, Shaw Simon J, Sundermann Kurt F, Zhang Dan, Petryka Joseph, Mendoza Esteban, Liu Fenghua, Myles David C, LaMarche Matthew J, Hirose Tomoyasu, Scott Freeze B, Smith Amos B
机构信息
Department of Chemistry, Kosan Biosciences Inc, 3832 Bay Center Place, Hayward, CA 94545, USA.
出版信息
Bioorg Med Chem Lett. 2004 May 3;14(9):2335-8. doi: 10.1016/j.bmcl.2004.01.102.
PMID:15081036
Abstract
A series of 7-deoxy discodermolide analogues in which the lactone fragment 'C' was replaced by aryl substituents were designed, synthesized, and evaluated for cytotoxicity.
摘要
设计、合成并评估了一系列7-脱氧多球海绵素类似物，其中内酯片段“C”被芳基取代基所取代，并对其细胞毒性进行了评估。
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