Goodwin Renee D, Stein Murray B
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, N.Y., USA.
Psychother Psychosom. 2003 Jan-Feb;72(1):10-5. doi: 10.1159/000067184.
The goal of the current study was to determine the association between personality factors and peptic ulcer disease (PUD) among adults in the general population.
Data were drawn from the Midlife Development in the United States Survey (MIDUS), a representative household survey of the adult population (ages 25-74; n = 3,032) of the United States. Multiple logistic regression analyses were used to determine the association between the big five personality factors and PUD, adjusting for differences in sociodemographic characteristics, psychiatric and physical comorbidity.
Neuroticism was associated with significantly increased odds of PUD [OR = 1.5 (95% CI: 1.03, 2.4)], which persisted after controlling for differences in sociodemographic characteristics, cigarette smoking, perception of poor health, comorbid mental disorders and physical illnesses. This relationship was specific to neuroticism.
These findings are consistent with and extend previous clinical and epidemiologic data by providing evidence of an independent association between neuroticism and PUD among adults in the general population. Future work investigating the relationship between neuroticism and the development of PUD in prospective data, including objective measures of physical and mental health status, may contribute to our understanding of this association.
本研究的目的是确定一般人群中成年人的人格因素与消化性溃疡疾病（PUD）之间的关联。
数据来自美国中年发展调查（MIDUS），这是一项针对美国成年人口（年龄在25 - 74岁；n = 3,032）的代表性家庭调查。采用多元逻辑回归分析来确定大五人格因素与PUD之间的关联，并对社会人口学特征、精神和身体合并症的差异进行调整。
神经质与PUD的患病几率显著增加相关[比值比（OR）= 1.5（95%置信区间：1.03, 2.4）]，在控制了社会人口学特征、吸烟、健康状况差的认知、合并精神障碍和身体疾病的差异后，这种关联仍然存在。这种关系是神经质所特有的。
这些发现与先前的临床和流行病学数据一致，并通过提供一般人群中成年人神经质与PUD之间独立关联的证据进行了扩展。未来在前瞻性数据中研究神经质与PUD发生之间关系的工作，包括身心健康状况的客观测量，可能有助于我们理解这种关联。
