Brown Darron R, Legge Denise, Qadadri Brahim
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Sex Transm Dis. 2002 Dec;29(12):763-8. doi: 10.1097/00007435-200212000-00005.
Women evaluated for sexually transmitted diseases (STDs) may be at increased risk for human papillomavirus (HPV) infection, a condition associated with cervical dysplasia. The distribution of HPV types in such a population is unknown.
The goal was to determine the prevalence of HPV infection, the distribution of HPV types, and the type distribution in relation to cervical dysplasia in women in an STD clinic.
Cervicovaginal lavage and Papanicolaou smear specimens were obtained from 295 women. Lavage specimens were analyzed for HPV by polymerase chain reaction/reverse blot strip assay.
Cervical cytologic findings were abnormal for 19.7% of women. HPV DNA was detected in 49.2% of women (high-risk HPV in 42.4%). HPV positivity correlated with the degree of cytologic abnormality. In women with dysplasia, HPV types 16, 66, 83, 56, 52, and 59 were commonly detected. Specimens containing abundant HPV DNA occurred most often in women with dysplasia.
HPV infection was common in women attending an STD clinic. Numerous individual HPV types were associated with cervical dysplasia, including "low-risk" types.
因性传播疾病（STD）接受评估的女性感染人乳头瘤病毒（HPV）的风险可能更高，HPV感染与宫颈发育异常有关。此类人群中HPV各型的分布情况尚不清楚。
确定性病门诊女性中HPV感染的患病率、HPV各型的分布情况以及与宫颈发育异常相关的型别分布。
从295名女性中获取宫颈阴道灌洗样本和巴氏涂片样本。通过聚合酶链反应/反向印迹条带分析法对灌洗样本进行HPV分析。
19.7%的女性宫颈细胞学检查结果异常。49.2%的女性检测到HPV DNA（42.4%为高危型HPV）。HPV阳性与细胞学异常程度相关。在发育异常的女性中，常见检测到的HPV型别为16、66、83、56、52和59型。含有大量HPV DNA的样本最常出现在发育异常的女性中。
在性病门诊就诊的女性中HPV感染很常见。许多HPV型别与宫颈发育异常有关，包括“低危”型别。
