28种小鼠品系的食物摄入量、饮水量及饮水口偏好
Food intake, water intake, and drinking spout side preference of 28 mouse strains.
作者信息
Bachmanov Alexander A, Reed Danielle R, Beauchamp Gary K, Tordoff Michael G
机构信息
Monell Chemical Senses Center, 3500 Market St., Philadelphia, Pennsylvania 19104, USA.
出版信息
Behav Genet. 2002 Nov;32(6):435-43. doi: 10.1023/a:1020884312053.
Male mice from 28 inbred strains (129P3/J, A/J, AKR/J, BALB/cByJ, BUB/BnJ, C3H/HeJ, C57BL/6J, C57L/J, CAST/Ei, CBA/J, CE/J, DBA/2J, FVB/NJ, I/LnJ, KK/H1J, LP/J, NOD/LtJ, NZB/B1NJ, P/J, PL/J, RBF/DnJ, RF/J, RIIIS/J, SEA/GnJ, SJL/J, SM/J, SPRET/Ei, and SWR/J) were fed chow and had access to two water bottles. Body weight, food intake, water intake, and drinking spout side preference were measured. There were large strain differences in all the measures collected, with at least a two-fold difference between strains with the lowest and the highest trait values. Estimates of heritability ranged from 0.36 (spout side preference) to 0.87 (body weight). Body weight, food intake, and water intake were interrelated among the strains, although substantial strain variation in food and water intakes independent from body weight was present. The strain differences described here provide useful information for designing mutagenesis screens and choosing strains for genetic mapping studies.
来自28个近交系雄性小鼠（129P3/J、A/J、AKR/J、BALB/cByJ、BUB/BnJ、C3H/HeJ、C57BL/6J、C57L/J、CAST/Ei、CBA/J、CE/J、DBA/2J、FVB/NJ、I/LnJ、KK/H1J、LP/J、NOD/LtJ、NZB/B1NJ、P/J、PL/J、RBF/DnJ、RF/J、RIIIS/J、SEA/GnJ、SJL/J、SM/J、SPRET/Ei和SWR/J）喂食普通饲料，并可使用两个水瓶。测量了体重、食物摄入量、饮水量和饮水口偏好。在所有收集的测量指标中，品系间存在很大差异，最低和最高性状值的品系之间至少有两倍的差异。遗传力估计值范围从0.36（饮水口偏好）到0.87（体重）。品系间体重、食物摄入量和饮水量相互关联，尽管食物和水摄入量存在与体重无关的显著品系差异。这里描述的品系差异为设计诱变筛选和选择用于基因定位研究的品系提供了有用信息。
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