Zilles K, Palomero-Gallagher N, Grefkes C, Scheperjans F, Boy C, Amunts K, Schleicher A
Institute of Medicine, Forschungszentrum Jülich, D-52425, Jülich, Germany.
Eur Neuropsychopharmacol. 2002 Dec;12(6):587-99. doi: 10.1016/s0924-977x(02)00108-6.
The density of transmitter receptors varies between different locations in the human cerebral cortex. We hypothesized that this variation may reflect the cyto- and myeloarchitectonical as well as the functional organisation of the cortex. We compared data from different imaging modalities (postmortem studies: cyto- and myeloarchitecture, quantitative in vitro receptor autoradiography; in vivo studies: PET receptor neuroimaging) in order to test our hypothesis. The regional and laminar distribution of the densities of numerous receptor types representing all classical transmitter systems as well as the adenosine system are visualized and measured in different cortical areas. The receptor distribution patterns segregate motor, primary sensory, unimodal sensory, multimodal association and other functionally identified cortical areas from each other. Areas of similar function show similar receptor fingerprints and differ from those with other properties. Thus, receptor distribution patterns reflect an organisational structure strictly correlated with the architectonics and functions of the human cerebral cortex.
人类大脑皮层不同位置的递质受体密度各不相同。我们推测这种差异可能反映了皮层的细胞结构、髓鞘结构以及功能组织。为了验证我们的假设，我们比较了来自不同成像方式的数据（死后研究：细胞结构和髓鞘结构、定量体外受体放射自显影；活体研究：PET受体神经成像）。在不同的皮层区域可视化并测量了代表所有经典递质系统以及腺苷系统的多种受体类型的密度的区域和层状分布。受体分布模式将运动、初级感觉、单峰感觉、多峰联合以及其他功能已确定的皮层区域彼此区分开来。功能相似的区域显示出相似的受体特征，并且与具有其他特性的区域不同。因此，受体分布模式反映了一种与人类大脑皮层的结构和功能严格相关的组织结构。
