Ishii Keisuke, Aoki Yoichi, Sasaki Masaru, Tanaka Kenichi
Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi dori, Niigata 951-8510, Japan.
Gynecol Oncol. 2002 Oct;87(1):150-1. doi: 10.1006/gyno.2002.6788.
Syndrome of inappropriate secretion of antidiuretic hormone induced by intraarterial cisplatin therapy is a previously unreported complication.
A 63-year-old woman with stage Ib2 squamous cell carcinoma of the cervix was treated with intraarterial cisplatin infusion in a neoadjuvant setting. Four days following the second course of chemotherapy, she became drowsy with severe fatigue and decreased mental awareness. Blood tests showed sodium of 110 mEq/L. Urine and plasma osmolarities were 308 and 240 mOsm/kg, respectively, confirming the diagnosis of a syndrome of inappropriate secretion of antidiuretic hormone induced by intra-arterial cisplatin infusion.
The potential for development of clinically significant hyponatremia early in the course of cisplatin therapy with any infusion routes emphasizes the need to closely monitor patients.
动脉内顺铂治疗引起的抗利尿激素分泌不当综合征是一种此前未报道过的并发症。
一名63岁患有宫颈Ib2期鳞状细胞癌的女性在新辅助治疗中接受了动脉内顺铂输注。在第二个化疗疗程后的第四天，她变得嗜睡，伴有严重疲劳和意识减退。血液检查显示钠浓度为110 mEq/L。尿液和血浆渗透压分别为308和240 mOsm/kg，证实了动脉内顺铂输注引起的抗利尿激素分泌不当综合征的诊断。
在顺铂治疗过程中，无论采用何种输注途径，早期都有发生具有临床意义的低钠血症的可能性，这强调了密切监测患者的必要性。
