Palaia Innocenza, Angioli Roberto, Cutillo Giuseppe, Manci Natalina, Panici Pierluigi Benedetti
Department of Gynaecology, University of Rome Campus Biomedico, Via Longoni 69, 00155 Rome, Italy.
Gynecol Oncol. 2002 Oct;87(1):155-6. doi: 10.1006/gyno.2002.6808.
Cutaneous lymphangitis carcinomatosis from cervical carcinoma is a very rare form of tumor metastatization; only anecdotal cases are reported in the literature. Most of the patients with skin relapse experienced metastasis as a single or multiple nodules.
A case of cutaneous lymphangitis carcinomatosis mimicking contact dermatitis was diagnosed at our institution in a patient affected by cervical carcinoma stage IIB. Palliative chemotherapy with paclitaxel was started and the patient experienced complete clinical response. The hypothetical mechanism of spread and the unusual manifestation of relapse are described.
In a woman with a history of cervical cancer, a diffuse pruritic skin eruption should alert the clinician to the possibility of cutaneous carcinomatous lymphangitis. If a lymphangitis carcinomatosis is diagnosed, systemic intravenous chemotherapy should be considered.
宫颈癌引起的皮肤淋巴管癌病是一种非常罕见的肿瘤转移形式;文献中仅报道过个别病例。大多数皮肤复发患者表现为单个或多个结节状转移。
我院诊断出一例模仿接触性皮炎的皮肤淋巴管癌病,患者为IIB期宫颈癌。开始使用紫杉醇进行姑息化疗,患者获得了完全的临床缓解。文中描述了可能的扩散机制及复发的不寻常表现。
对于有宫颈癌病史的女性,弥漫性瘙痒性皮疹应提醒临床医生注意皮肤癌性淋巴管炎的可能性。如果诊断为淋巴管癌病,应考虑全身静脉化疗。