Blair Robert M, Appt Susan E, Bennetau-Pelissero Catherine, Clarkson Thomas B, Anthony Mary S, Lamothe Valerie, Potter Susan M
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.
J Nutr. 2002 Dec;132(12):3585-91. doi: 10.1093/jn/132.12.3585.
The specific components of soy responsible for its beneficial effects on plasma lipids are unknown. Golden Syrian F(1)B Hybrid hamsters (75 male, 74 female) were evaluated for the effect of dietary soy and soy isoflavones on plasma lipids. They were fed the following diets for 16 wk: casein/lactalbumin (C/L), soy protein with isoflavones [Soy(+)], soy protein with isoflavones removed [Soy(-)], Soy(-) plus isoflavone extract (IF), and C/L + IF. At necropsy, plasma total cholesterol, HDL cholesterol (HDLC), LDL + VLDL cholesterol (LDL + VLDLC), isoflavones, and uterine and accessory gland weights were measured. Male hamsters fed the three soy-containing diets had lower LDL + VLDLC concentrations than those fed the two C/L diets (P < 0.01), and those fed Soy(-) + IF did not differ from those fed Soy(+). In females, diet did not affect plasma LDL + VLDLC concentration. Females fed Soy(+) or Soy(-) had higher HDLC (P < 0.05) than those fed C/L. HDLC was not affected by diet in males. Due to higher equol production (P < 0.01), males had greater plasma isoflavone concentrations (P < 0.01) than females. There was a positive association between plasma total isoflavones and LDL + VLDLC (r = 0.65, P < 0.05) in females. These data suggest gender differences in plasma lipid and isoflavone responses to soy- based diets in Syrian F(1)B Hybrid hamsters, which offer an opportunity to explore effects of sex hormones on isoflavone metabolism and the effects of isoflavones on lipid metabolism.
大豆中对血浆脂质产生有益作用的具体成分尚不清楚。对金黄叙利亚F(1)B杂种仓鼠（75只雄性，74只雌性）进行了膳食大豆和大豆异黄酮对血浆脂质影响的评估。给它们喂食以下饮食16周：酪蛋白/乳白蛋白（C/L）、含异黄酮的大豆蛋白[Soy(+)]、去除异黄酮的大豆蛋白[Soy(-)]、Soy(-)加异黄酮提取物（IF），以及C/L + IF。尸检时，测量血浆总胆固醇、高密度脂蛋白胆固醇（HDLC）、低密度脂蛋白+极低密度脂蛋白胆固醇（LDL + VLDLC）、异黄酮，以及子宫和附属腺重量。喂食三种含大豆饮食的雄性仓鼠的LDL + VLDLC浓度低于喂食两种C/L饮食的仓鼠（P < 0.01），喂食Soy(-) + IF的仓鼠与喂食Soy(+)的仓鼠没有差异。在雌性中，饮食不影响血浆LDL + VLDLC浓度。喂食Soy(+)或Soy(-)的雌性的HDLC高于喂食C/L的雌性（P < 0.05）。饮食对雄性的HDLC没有影响。由于雌马酚产量较高（P < 0.01），雄性的血浆异黄酮浓度高于雌性（P < 0.01）。雌性血浆总异黄酮与LDL + VLDLC之间存在正相关（r = 0.65，P < 0.05）。这些数据表明，叙利亚F(1)B杂种仓鼠对大豆基饮食的血浆脂质和异黄酮反应存在性别差异，这为探索性激素对异黄酮代谢的影响以及异黄酮对脂质代谢的影响提供了机会。
