Balmir F, Staack R, Jeffrey E, Jimenez M D, Wang L, Potter S M
Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, 61801, USA.
J Nutr. 1996 Dec;126(12):3046-53. doi: 10.1093/jn/126.12.3046.
The effects of an ethanol-acetone extract from soy flour on serum lipids and thyroid hormones were studied in rats and hamsters. In Study 1, male Sprague-Dawley rats were fed diets containing protein from ethanol-acetone extracted isolated soy protein (ISP-), nonextracted ISP (ISP), casein (casein-), or casein to which 0.36 mg ethanol-acetone extract/g protein was added (casein+). Rats fed either ISP-containing diet had lower serum total cholesterol concentrations compared with those fed either casein diet (P < 0.05). Lower serum LDL-cholesterol concentrations were present in rats fed either ISP-containing diet and in those fed casein+ compared with those fed casein- (P < 0.05). Adding the extract to casein (casein+) produced higher serum thyroxine concentration and free thyroxine indices compared with all other groups (P < 0.05). In Study 2, male Golden Syrian hamsters were fed experimental diets containing protein from ISP, ISP with added ethanol-acetone extract (0.36 mg extract/g protein; ISP+), casein-, casein+ (0.36 mg extract/g protein), or casein with twice the level of extract (0.72 mg/g protein; casein++). Lower serum total cholesterol and LDL (LDL + VLDL + IDL) cholesterol concentrations were observed in hamsters fed ISP, ISP+ or casein+ compared with those fed casein- (P < 0.05). Addition of the extract at higher levels to casein (casein++) did not lower serum lipids relative to those fed casein-. Serum thyroxine concentration and the free thyroxine index were greater in both ISP groups as well as in hamsters fed casein++ compared with those fed casein- or casein+ (P < 0.05). In conclusion, both studies show that protein from soybeans decreases serum total and LDL cholesterol while the effects on thyroxine are different in rats and hamsters. It is also apparent that the ethanol-acetone extract of soy flour produces changes in serum cholesterol, particularly in the LDL fraction in both species.
研究了大豆粉乙醇 - 丙酮提取物对大鼠和仓鼠血清脂质及甲状腺激素的影响。在研究1中，给雄性Sprague-Dawley大鼠喂食含有来自乙醇 - 丙酮提取的分离大豆蛋白（ISP-）、未提取的ISP（ISP）、酪蛋白（酪蛋白-）的蛋白质的饲料，或添加了0.36毫克乙醇 - 丙酮提取物/克蛋白质的酪蛋白饲料（酪蛋白+）。与喂食酪蛋白饲料的大鼠相比，喂食含ISP饲料的大鼠血清总胆固醇浓度较低（P < 0.05）。与喂食酪蛋白-的大鼠相比，喂食含ISP饲料的大鼠和喂食酪蛋白+的大鼠血清低密度脂蛋白胆固醇浓度较低（P < 0.05）。与所有其他组相比，向酪蛋白中添加提取物（酪蛋白+）可使血清甲状腺素浓度和游离甲状腺素指数更高（P < 0.05）。在研究2中，给雄性金黄叙利亚仓鼠喂食含有来自ISP、添加了乙醇 - 丙酮提取物的ISP（0.36毫克提取物/克蛋白质；ISP+）、酪蛋白-、酪蛋白+（0.36毫克提取物/克蛋白质）或提取物水平加倍（0.72毫克/克蛋白质；酪蛋白++）的酪蛋白的实验饲料。与喂食酪蛋白-的仓鼠相比，喂食ISP、ISP+或酪蛋白+的仓鼠血清总胆固醇和低密度脂蛋白（低密度脂蛋白 + 极低密度脂蛋白 + 中间密度脂蛋白）胆固醇浓度较低（P < 0.05）。与喂食酪蛋白-的仓鼠相比，向酪蛋白中添加更高水平的提取物（酪蛋白++）并没有降低血清脂质。与喂食酪蛋白-或酪蛋白+的仓鼠相比，两个ISP组以及喂食酪蛋白++的仓鼠血清甲状腺素浓度和游离甲状腺素指数更高（P < 0.05）。总之，两项研究均表明，大豆蛋白可降低血清总胆固醇和低密度脂蛋白胆固醇，而对甲状腺素的影响在大鼠和仓鼠中有所不同。同样明显的是，大豆粉的乙醇 - 丙酮提取物会引起血清胆固醇变化，特别是在这两个物种的低密度脂蛋白部分。
