Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Institute of Medical Information/Medical Library, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Adv Nutr. 2023 Nov;14(6):1633-1643. doi: 10.1016/j.advnut.2023.09.008. Epub 2023 Sep 25.
The effects of isoflavones on postmenopausal female's blood lipid profile have yielded conflicting results in previous studies. Further investigation is necessary to determine the potential benefits of isoflavone therapy in managing cardiovascular health in this population. This meta-analysis aimed to assess the effects of isoflavones on blood lipid concentrations in postmenopausal females. A comprehensive search was conducted in major databases for randomized controlled trials published between 2000 and 2023. Eighteen studies were included in the analysis, which examined the impact of isoflavone intake on blood lipids in postmenopausal females. Isoflavone consumption resulted in a significant reduction in triacylglycerol (TG) concentrations (-12.50 mg/dL; 95% CI: -23.09, -1.91) and a modest increase in high-density lipoprotein cholesterol (HDL cholesterol) concentrations (1.83 mg/dL; 95% CI: 0.03, 3.64). Subgroup analysis showed that isoflavones significantly decreased TG (-15.79 mg/dL; 95% CI: -28.36, -3.22) and increased HDL cholesterol (2.49 mg/dL; 95% CI: 1.80, 3.19) in postmenopausal females under 65 y old. No significant effects were observed in females over 65 y old. Both low (≤80 mg/d) and high (>80 mg/d) doses of isoflavones exhibited TG-lowering effects, whereas only the high dose increased HDL cholesterol. Longer treatment duration (≥24 wk) was associated with a significant reduction in TG, whereas HDL cholesterol improvement occurred during the early period (<24 wk) of supplementation. The consumption of isoflavones resulted in a significant reduction in TG concentrations and an increase in HDL cholesterol concentrations among postmenopausal females under 65 y of age.
异黄酮对绝经后女性血脂谱的影响在以前的研究中得出了相互矛盾的结果。有必要进一步研究以确定异黄酮治疗在管理该人群心血管健康方面的潜在益处。这项荟萃分析旨在评估异黄酮对绝经后女性血脂浓度的影响。在主要数据库中进行了全面检索，以查找 2000 年至 2023 年期间发表的随机对照试验。分析包括了 18 项研究，这些研究检查了异黄酮摄入对绝经后女性血脂的影响。异黄酮的摄入导致甘油三酯（TG）浓度显著降低（-12.50 mg/dL；95%CI：-23.09，-1.91），高密度脂蛋白胆固醇（HDL 胆固醇）浓度适度升高（1.83 mg/dL；95%CI：0.03，3.64）。亚组分析表明，异黄酮可显著降低 65 岁以下绝经后女性的 TG（-15.79 mg/dL；95%CI：-28.36，-3.22）和升高 HDL 胆固醇（2.49 mg/dL；95%CI：1.80，3.19）。而在 65 岁以上的女性中未观察到显著影响。低剂量（≤80mg/d）和高剂量（>80mg/d）异黄酮均表现出降低 TG 的作用，而仅高剂量增加了 HDL 胆固醇。治疗时间更长（≥24 周）与 TG 显著降低相关，而 HDL 胆固醇的改善发生在补充的早期（<24 周）。异黄酮的摄入可显著降低 65 岁以下绝经后女性的 TG 浓度并增加 HDL 胆固醇浓度。
