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莱姆病相关性假脑瘤:一例报告及文献综述

Pseudotumor cerebri in Lyme disease: a case report and literature review.

作者信息

Kan L, Sood S K, Maytal J

机构信息

Division of Pediatric Neurology, Schneider Children's Hospital, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA.

出版信息

Pediatr Neurol. 1998 May;18(5):439-41. doi: 10.1016/s0887-8994(97)00215-4.

DOI:10.1016/s0887-8994(97)00215-4
PMID:9650688
Abstract

Pseudotumor cerebri is an unusual presentation of Lyme disease. The case of an 8-year-old girl with pseudotumor cerebri secondary to acute neuroborreliosis is reported. She presented with acute onset of headache, papilledema, sixth nerve palsy, increased intracranial pressure, and cerebrospinal fluid pleocytosis. Serum and cerebrospinal fluid Lyme antibodies were positive. Twelve reported cases that mostly presented with systemic findings and signs of Lyme disease before development of pseudotumor cerebri were reviewed. We conclude that acute neuroborreliosis can present with pseudotumor cerebri as an initial manifestation. It is important to include Lyme disease in the differential diagnosis of pseudotumor cerebri in an area endemic for Lyme disease.

摘要

假性脑瘤是莱姆病的一种不寻常表现形式。本文报告了一例8岁患有急性神经型莱姆病继发假性脑瘤的女孩病例。她表现为急性起病的头痛、视乳头水肿、展神经麻痹、颅内压升高和脑脊液细胞增多。血清和脑脊液莱姆抗体均为阳性。我们回顾了12例已报告病例,这些病例大多在出现假性脑瘤之前表现出莱姆病的全身症状和体征。我们得出结论,急性神经型莱姆病可最初表现为假性脑瘤。在莱姆病流行地区,将莱姆病纳入假性脑瘤的鉴别诊断很重要。

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Pseudotumor cerebri in Lyme disease: a case report and literature review.莱姆病相关性假脑瘤:一例报告及文献综述
Pediatr Neurol. 1998 May;18(5):439-41. doi: 10.1016/s0887-8994(97)00215-4.
2
[Pseudotumor cerebri caused by Lyme borreliosis].[莱姆病螺旋体病所致假脑瘤]
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引用本文的文献

1
Lyme Neuroborreliosis Presenting with Isolated Intracranial Hypertension: A Case Report.以孤立性颅内高压为表现的莱姆病神经疏螺旋体病:一例报告
Case Rep Neurol. 2025 May 26;17(1):72-78. doi: 10.1159/000546097. eCollection 2025 Jan-Dec.
2
Neurosurgical management of intracranial hypertension in pediatric neuroborreliosis: a systematic literature review.小儿神经莱姆病颅内高压的神经外科治疗:一项系统文献综述
Neurosurg Rev. 2025 Apr 21;48(1):372. doi: 10.1007/s10143-025-03533-x.
3
Lyme Disease and Papilledema: A Retrospective Study on Clinical Characteristics and Outcomes.
莱姆病合并视乳头水肿:一项临床特征和结局的回顾性研究。
J Child Neurol. 2024 Aug;39(9-10):334-342. doi: 10.1177/08830738241273376. Epub 2024 Sep 2.
4
Prospective, Cross-Sectional Study Finds No Common Viruses in Cerebrospinal Fluid of Children with Pseudotumor Cerebri.前瞻性横断面研究发现假性脑瘤患儿脑脊液中无常见病毒。
Brain Sci. 2023 Feb 19;13(2):361. doi: 10.3390/brainsci13020361.
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Lyme Neuroborreliosis: Mechanisms of Infection of the Nervous System.莱姆病神经伯氏疏螺旋体病:神经系统感染机制
Brain Sci. 2021 Jun 15;11(6):789. doi: 10.3390/brainsci11060789.
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Lyme Neuroborreliosis in Children.儿童莱姆病性神经伯氏疏螺旋体病
Brain Sci. 2021 Jun 7;11(6):758. doi: 10.3390/brainsci11060758.
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Papilledema as the Sole Manifestation of Neuroborreliosis.视乳头水肿作为神经莱姆病的唯一表现
Case Rep Infect Dis. 2021 May 30;2021:5565900. doi: 10.1155/2021/5565900. eCollection 2021.
8
Lyme Disease in Humans.人类莱姆病。
Curr Issues Mol Biol. 2021;42:333-384. doi: 10.21775/cimb.042.333. Epub 2020 Dec 11.
9
A rare case of pseudotumor cerebri in adult Lyme disease.成人莱姆病伴发假脑瘤的罕见病例。
Clin Case Rep. 2019 Dec 18;8(1):116-119. doi: 10.1002/ccr3.2582. eCollection 2020 Jan.
10
Pseudotumor cerebri comorbid with meningioma: A review and case series.假性脑瘤合并脑膜瘤:综述与病例系列
Surg Neurol Int. 2018 Jul 4;9:130. doi: 10.4103/sni.sni_484_17. eCollection 2018.