Yasuda Hiroki, Barth Alison L, Stellwagen David, Malenka Robert C
Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University School of Medicine, Stanford, California 94304, USA.
Nat Neurosci. 2003 Jan;6(1):15-6. doi: 10.1038/nn985.
Long-term potentiation (LTP) is thought to be critically involved not only in learning and memory, but also during the activity-dependent developmental phases of neural circuit formation and refinement. Whether the mechanisms underlying LTP change during this phase of postnatal development, however, is unknown. We report here that, unlike LTP in the more mature CA1 region of the hippocampus, LTP in neonatal rodent hippocampus (<9 postnatal days, <P9) requires cyclic AMP-dependent protein kinase A (PKA) but not Ca(2+)/calmodulin-dependent protein kinase II (CaMKII).
长期增强作用（LTP）不仅被认为在学习和记忆中起关键作用，而且在神经回路形成和完善的活动依赖发育阶段也发挥作用。然而，在出生后发育的这个阶段，LTP潜在机制是否发生变化尚不清楚。我们在此报告，与海马体更成熟的CA1区域中的LTP不同，新生啮齿动物海马体（出生后<9天，<P9）中的LTP需要环磷酸腺苷依赖性蛋白激酶A（PKA），而不需要钙/钙调蛋白依赖性蛋白激酶II（CaMKII）。
