Malysheva O A, Trufakin S V, Shirinskiĭ V S
Ter Arkh. 2002;74(10):48-52.
To study nervous regulation of cardiac rhythm (CR) in patients with rheumatoid arthritis (RA) and multiple sclerosis (MS).
Nervous regulation of cardiac rhythm was studied in 57 patients with RA and MS vs 40 healthy subjects.
It was found that nervous regulation of CR in RA and MS patients at rest is characterized by imbalance of functions of the autonomic nervous system with enhancement of ergotropic effects in patients with RA and deficiency of trophotropic impacts in growing ergotropic component in patients with MS. Stress tests led to dysfunction of CR central regulation with disturbed activity of the subcortical nervous centers (SNC) and autonomic maintenance of the processes, were characterized in emotional stress by insufficient activity of SNC and enhancement of parasympathetic effects in RA patients, hyperactivation of SNC with intensification of sympathetic impacts in MS patients manifesting in destabilizing effect of the sympathetic nervous system in both groups of patients.
The findings should be taken into consideration when vegetotropic drugs are used in the treatment of RA and MS patients.
研究类风湿关节炎（RA）和多发性硬化症（MS）患者的心脏节律（CR）的神经调节。
对57例RA和MS患者以及40名健康受试者的心脏节律神经调节进行了研究。
发现RA和MS患者静息时CR的神经调节表现为自主神经系统功能失衡，RA患者的促肾上腺能作用增强，而MS患者在促肾上腺能成分增加时营养性影响不足。应激试验导致CR中枢调节功能障碍，伴有皮质下神经中枢（SNC）活动紊乱以及自主神经系统对这些过程的维持，在情绪应激时，RA患者表现为SNC活动不足和副交感神经作用增强，MS患者则表现为SNC过度激活以及交感神经影响增强，两组患者均表现为交感神经系统的不稳定作用。
在使用营养性药物治疗RA和MS患者时应考虑这些发现。
