钙/钙调蛋白依赖性蛋白激酶II在神经元可塑性和记忆形成中的作用。
Participation of CaMKII in neuronal plasticity and memory formation.
作者信息
Cammarota Martín, Bevilaqua Lia R M, Viola Haydée, Kerr Daniel S, Reichmann Bruno, Teixeira Viviane, Bulla Mário, Izquierdo Iván, Medina Jorge H
机构信息
Centro de Memória, Departamento de Bioquímica, ICBS, UFRGS, Porto Alegre, Brasil.
出版信息
Cell Mol Neurobiol. 2002 Jun;22(3):259-67. doi: 10.1023/a:1020763716886.
Abstract
- The unique biochemical properties of Ca(2+)/calmodulin (CaM)-dependent protein kinase II have made this enzyme one of the paradigmatic models of the forever searched "memory molecule." 2. In particular, the central participation of CaMKII as a sensor of the Ca(2+) signals generated by activation of NMDA receptors after the induction of long-term plastic changes, has encouraged the use of pharmacological, genetic, biochemical, and imaging tools to unveil the role of this kinase in the acquisition, consolidation, and expression of different types of memories. 3. Here we review some of the more exciting discoveries related to the mechanisms involved in CaMKII activation and synaptic plasticity.
摘要
- Ca(2+)/钙调蛋白（CaM）依赖性蛋白激酶II独特的生化特性，使其成为一直以来所探寻的“记忆分子”的典型模型之一。2. 特别是，在长期可塑性变化诱导后，CaMKII作为N-甲基-D-天冬氨酸（NMDA）受体激活所产生的Ca(2+)信号的传感器发挥核心作用，这促使人们运用药理学、遗传学、生物化学和成像工具来揭示该激酶在不同类型记忆的获取、巩固和表达中的作用。3. 在此，我们回顾一些与CaMKII激活及突触可塑性相关机制的更令人兴奋的发现。
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