小鼠T淋巴细胞和B淋巴细胞的放射敏感性
The radiosensitivity of T and B lymphocytes in mice.
作者信息
Kataoka Y, Sado T
出版信息
Immunology. 1975 Jul;29(1):121-30.
The radiosensitivity of T and B lymphocytes in spleens of specific pathogen-free C3Hf/HeMs male mice was studied by the direct and indirect immunofluorescence technique. It was found that the radiobiological parameters characterizing the survival curve of Bpsi lymphocytes were DO = 200 R and n = 1-00. The T lymphocytes, on the other hand, were shown to consist of two distinct subpopulations with respect to their radiosensitivity. The radiobiological parameters of the radiosensitive fraction of T lymphocytes were Dq = 185 R, DO =195 R and n = 2-50. The DO value of the radioresistant T lymphocyte subpopulation was practically unmeasurable. It was estimated that approximately 8 per cent of the T lymphocytes present in the spleen of normal C3Hf mice belonged to this radioresistant subpopulation.
采用直接和间接免疫荧光技术，研究了无特定病原体的C3Hf/HeMs雄性小鼠脾脏中T和B淋巴细胞的放射敏感性。结果发现，表征Bpsi淋巴细胞存活曲线的放射生物学参数为：DO = 200伦琴，n = 1.00。另一方面，T淋巴细胞在放射敏感性方面表现为两个不同的亚群。放射敏感的T淋巴细胞亚群的放射生物学参数为：Dq = 185伦琴，DO = 195伦琴，n = 2.50。抗辐射T淋巴细胞亚群的DO值几乎无法测量。据估计，正常C3Hf小鼠脾脏中约8%的T淋巴细胞属于该抗辐射亚群。
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