结构重排患者交换点的非随机分布。
Nonrandom distribution of exchange points in patients with structural rearrangements.
作者信息
Nakagome Y, Chiyo H
出版信息
Am J Hum Genet. 1976 Jan;28(1):31-41.
Abstract
High resolution studies of structural rearrangements were carried out using the G-band technique. A total of 220 breakage points were identified within individual bands from 117 unrelated cases born with a structural rearrangement. Breakage points were not evenly distributed along chromosomes in terms of G-band patterns. There was an excess involvement of light bands and a striking lack of dark bands in both reciprocal translocations and inversions. In reciprocal translocations, the middle part of a chromosome arm has less chance of being the site of an exchange than the terminal and centromeric parts. The implications of these results are briefly discussed.
摘要
利用G带技术对结构重排进行了高分辨率研究。在117例出生时患有结构重排的无关病例的各个带内共确定了220个断裂点。就G带模式而言，断裂点在染色体上分布不均。在相互易位和倒位中，浅带受累过多，深带明显缺乏。在相互易位中，染色体臂的中部比末端和着丝粒部分成为交换位点的机会更少。简要讨论了这些结果的意义。
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本文引用的文献
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Exp Cell Res. 1972 Sep;74(1):293-5. doi: 10.1016/0014-4827(72)90510-1.
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Segregation of genetic markers in families with chromosome polymorphisms and structural rearrangements involving chromosome 1.具有染色体多态性和涉及1号染色体结构重排的家族中遗传标记的分离。
Ann Hum Genet. 1974 Jan;37(3):261-74. doi: 10.1111/j.1469-1809.1974.tb01834.x.
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Partial trisomy 14 following a balanced reciprocal translocation t(14q-;21q+).平衡易位t(14q-;21q+)后发生的14号染色体部分三体。
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Evidence for an inverse relationship between x-ray induced chromatid and chromosome breakage in human chromosomes.X射线诱导的人类染色体染色单体和染色体断裂之间存在负相关关系的证据。
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