Weber Lutz
Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Curr Med Chem. 2002 Dec;9(23):2085-93. doi: 10.2174/0929867023368719.
Multi-component reactions (MCRs) enable the facile, automated and high throughput generation of small organic molecules. MCRs have been used to create diversity oriented and biased combinatorial libraries, to accomplish the synthesis of highly complex natural products as well as for the large-scale production of drug candidates. This provides medicinal chemists with a powerful tool to create novel chemical diversity, matching the space of biological targets with relevant chemistry. The discovery of novel MCRs has become an increasingly active area of research, yielding novel chemical scaffolds for drug discovery efforts.
多组分反应（MCRs）能够轻松、自动且高通量地生成有机小分子。多组分反应已被用于构建多样化导向和偏向性的组合文库，以完成高度复杂天然产物的合成以及药物候选物的大规模生产。这为药物化学家提供了一个强大的工具，用于创造新的化学多样性，使生物靶点空间与相关化学相匹配。新型多组分反应的发现已成为一个日益活跃的研究领域，为药物研发工作带来了新的化学骨架。
