Boon J Middleton, Smith Bradley D
Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Curr Opin Chem Biol. 2002 Dec;6(6):749-56. doi: 10.1016/s1367-5931(02)00399-x.
An increasing number of synthetic compounds have been shown to facilitate ion and polar molecule transport across bilayer membranes. Most notably, recent advances in anion transport have yielded synthetic chloride channels and phospholipid translocases. Attention has also turned to the ability of short amino acid sequences to transport peptides and proteins across cellular membranes.
越来越多的合成化合物已被证明能促进离子和极性分子跨双层膜运输。最值得注意的是,阴离子运输领域的最新进展已产生了合成氯离子通道和磷脂转位酶。人们的注意力也转向了短氨基酸序列跨细胞膜运输肽和蛋白质的能力。