Licen Sabina, De Riccardis Francesco, Izzo Irene, Tecilla Paolo
Department of Chemical Sciences, University of Trieste, Via L. Giorgieri 1, Trieste, Italy.
Curr Drug Discov Technol. 2008 Jun;5(2):86-97. doi: 10.2174/157016308784746319.
Anion transport across phospholipid membrane is a typical supramolecular function involving dynamic recognition of the substrate during the whole translocation process. Supramolecular chemists, taking inspiration by the natural anion transporters, have designed artificial systems able to mimic, at the functional level, several features of the natural ion channels. The scope of this research is twofold: on one hand to get insight on the molecular basis of recognition and transport, and on the other hand to get control of the biomedical relevant processes. The present review focuses on the synthetic systems promoting anion transport, covering both artificial channels and carriers that operate in phospholipid membrane. The design principles of such systems will be discussed together with the potential biomedical applications.
阴离子跨磷脂膜转运是一种典型的超分子功能，在整个转运过程中涉及对底物的动态识别。超分子化学家从天然阴离子转运体中获得灵感，设计出了能够在功能层面模拟天然离子通道若干特征的人工系统。这项研究的范围有两个方面：一方面是深入了解识别和转运的分子基础，另一方面是控制与生物医学相关的过程。本综述聚焦于促进阴离子转运的合成系统，涵盖在磷脂膜中起作用的人工通道和载体。将讨论此类系统的设计原理以及潜在的生物医学应用。
