Essama Mbia Jean-Jacques, Guérit Jean-Michel, Haufroid Vincent, Hantson Philippe
Department of Intensive Care, Cliniques St-Luc, Université Catholique de Louvain, Brussels, Belgium.
Am J Ophthalmol. 2002 Dec;134(6):914-6. doi: 10.1016/s0002-9394(02)01798-1.
To illustrate the safety and efficacy of fomepizole in a case of methanol poisoning with initial visual impairment.
Interventional case report.
A 60-year-old man was admitted with blurred vision and changes in color perception 18 hours after ingesting 100 ml methanol. Fomepizole was chosen for antidotal therapy in combination with hemodialysis. Flash electroretinogram (fERG) and flash visual evoked potentials (fVEPs) examinations were obtained at the bedside 2 hours after admission and on days 1 and 8. The monocular pattern-reversal visual evoked potentials (pVEPs) were investigated on days 1 and 8.
A complete reversal of visual impairment was achieved within 20 hours. An abnormal b-wave amplitude and an increased peak III latency at VEPs were present on admission and recovered within 24 hours.
Fomepizole appeared safe and effective for a patient who had severe methanol poisoning presenting with visual impairment.
阐述甲吡唑在一例初始伴有视力损害的甲醇中毒病例中的安全性和有效性。
介入性病例报告。
一名60岁男性在摄入100毫升甲醇18小时后因视力模糊和色觉改变入院。选择甲吡唑进行解毒治疗并联合血液透析。入院2小时后及第1天和第8天在床边进行闪光视网膜电图（fERG）和闪光视觉诱发电位（fVEP）检查。在第1天和第8天对单眼图形翻转视觉诱发电位（pVEP）进行研究。
20小时内视力损害完全逆转。入院时VEP的b波振幅异常且峰III潜伏期延长，24小时内恢复。
甲吡唑对于出现视力损害的严重甲醇中毒患者似乎安全有效。
