Hood Kathryn E, Dreschel Nancy A, Granger Douglas A
Department of Biobehavioral Health, The Pennsylvania State University, University Park 16802, USA.
Dev Psychobiol. 2003 Jan;42(1):17-34. doi: 10.1002/dev.10076.
To examine whether maternal responsiveness during interactions with endotoxin-treated pups contributes to long-term effects on social development, neonatal mice were fostered on postnatal day 1 to dams from three selectively bred lines that differ in social behaviors. On day 5, neonates were administered saline or 0.5 mg/kg endotoxin (lipopolysaccharide, i.p.). Observations of undisturbed dams and litters on days 2, 4, 6, and 8 showed modest line differences in maternal behaviors. At the peak intensity of the transient illness induced by endotoxin (3 hr postinjection on day 5), dams increased licking and decreased time off-nest for endotoxin, but not saline-treated pups. As adults, fostered-reared males were observed in brief social interactions. Males exposed to endotoxin early in life showed changes in adult social behaviors that depended on foster dam line as well as individual differences in maternal responsiveness. Maternal responsiveness to stressed neonates can ameliorate the social-developmental effects of early illness.
为了研究与经内毒素处理的幼崽互动期间母体的反应性是否会对社会发展产生长期影响，在出生后第1天将新生小鼠寄养给来自三个在社会行为上存在差异的选择性育种品系的母鼠。在第5天，给新生小鼠注射生理盐水或0.5 mg/kg内毒素（脂多糖，腹腔注射）。在第2、4、6和8天对未受干扰的母鼠和幼崽进行观察，结果显示母体行为存在适度的品系差异。在内毒素诱导的短暂疾病的强度峰值（第5天注射后3小时）时，母鼠对注射内毒素而非生理盐水的幼崽增加了舔舐行为，并减少了离巢时间。成年后，对寄养饲养的雄性小鼠进行了简短的社会互动观察。生命早期接触内毒素的雄性小鼠在成年后的社会行为发生了变化，这些变化取决于寄养母鼠的品系以及母体反应性的个体差异。母体对受应激新生小鼠的反应性可以改善早期疾病对社会发展的影响。
