Luther J A, Daftary S S, Boudaba C, Gould G C, Halmos K Cs, Tasker J G
Neuroscience Program, Molecular and Cellular Biology Program, and Neurobiology Division of the Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118-5698, USA.
J Neuroendocrinol. 2002 Dec;14(12):929-32. doi: 10.1046/j.1365-2826.2002.00867.x.
Parvocellular neurones of the hypothalamic paraventricular nucleus (PVN) comprise neurosecretory and non-neurosecretory subpopulations. We labelled neurosecretory neurones with intravenous injection of the retrograde tracer, fluoro-gold, and recorded from fluoro-gold-positive and negative PVN parvocellular neurones in hypothalamic slices. Non-neurosecretory parvocellular neurones generated a low-threshold spike (LTS) and robust T-type Ca2+ current, whereas neurosecretory neurones showed no LTS and a small T-current. LTS neurones were located in non-neurosecretory regions of the PVN, and non-LTS neurones were located in neurosecretory regions of the PVN. These findings indicate that neurosecretory and non-neurosecretory subtypes of parvocellular PVN neurones express distinct membrane electrical properties.
下丘脑室旁核（PVN）的小细胞神经元包括神经分泌和非神经分泌亚群。我们通过静脉注射逆行示踪剂氟金来标记神经分泌神经元，并在脑片上记录来自氟金阳性和阴性PVN小细胞神经元的电活动。非神经分泌小细胞神经元产生低阈值尖峰（LTS）和强大的T型Ca2+电流，而神经分泌神经元则未表现出LTS且T电流较小。LTS神经元位于PVN的非神经分泌区域，而非LTS神经元位于PVN的神经分泌区域。这些发现表明，PVN小细胞神经元的神经分泌和非神经分泌亚型表现出不同的膜电特性。
