Royo Maria, Escolano Beatriz Aznar, Madrigal M Pilar, Jurado Sandra
Institute of Neuroscience CSIC-UMH, Alicante, Spain.
Front Synaptic Neurosci. 2022 Jan 31;14:833449. doi: 10.3389/fnsyn.2022.833449. eCollection 2022.
AMPA receptors (AMPARs) are critical for mediating glutamatergic synaptic transmission and plasticity, thus playing a major role in the molecular machinery underlying cellular substrates of memory and learning. Their expression pattern, transport and regulatory mechanisms have been extensively studied in the hippocampus, but their functional properties in other brain regions remain poorly understood. Interestingly, electrophysiological and molecular evidence has confirmed a prominent role of AMPARs in the regulation of hypothalamic function. This review summarizes the existing evidence on AMPAR-mediated transmission in the hypothalamus, where they are believed to orchestrate the role of glutamatergic transmission in autonomous, neuroendocrine function, body homeostasis, and social behavior.
α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体（AMPA受体）对于介导谷氨酸能突触传递和可塑性至关重要，因此在记忆和学习的细胞基质的分子机制中发挥着主要作用。它们的表达模式、转运和调节机制已在海马体中得到广泛研究，但它们在其他脑区的功能特性仍知之甚少。有趣的是，电生理学和分子证据证实了AMPA受体在下丘脑功能调节中具有重要作用。本综述总结了关于下丘脑AMPA介导的传递的现有证据，据信它们在自主、神经内分泌功能、身体内稳态和社会行为中协调谷氨酸能传递的作用。
