Yoo Hwan Y, Galabova Violetta, Edwin David, Thuluvath Paul J
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Liver Transpl. 2002 Dec;8(12):1133-7. doi: 10.1053/jlts.2002.37000.
The outcome of liver transplantation is dependent on many factors. It was suggested that racial disparities in outcome may be related to differences in socioeconomic status (SES). In this retrospective study, we analyzed the effect of SES on graft and patient survival. Two hundred seventy-six adult patients who underwent liver transplantation at our institution from July 1988 to June 2001 were included in the analysis. Educational and occupation statuses were coded using established criteria (Hollingshead Index of Social Status [HI]). SES then was calculated using the HI formula: SES = education level x 3 + occupation x 5, and categorized into four groups: group 1, score less than 29 (n = 71); group 2, score of 29 to 42 (n = 82); group 3, score of 42 to 53 (n = 69); and group 4, score greater than 53 (n = 54). Kaplan-Meier analysis was used for graft and patient survival, and Cox regression analysis was used to determine the effect of confounding factors. Demographics of all four groups were similar. One-, 2-, and 5-year graft and patient survival did not differ significantly across groups by Kaplan-Meier and Cox regression survival analysis. In conclusion, SES did not predict graft and patient survival after liver transplantation.
肝移植的结果取决于许多因素。有人提出，结果中的种族差异可能与社会经济地位（SES）的差异有关。在这项回顾性研究中，我们分析了SES对移植物和患者生存的影响。分析纳入了1988年7月至2001年6月在我们机构接受肝移植的276例成年患者。使用既定标准（霍林斯黑德社会地位指数[HI]）对教育和职业状况进行编码。然后使用HI公式计算SES：SES = 教育水平×3 + 职业×5，并分为四组：第1组，得分低于29（n = 71）；第2组，得分29至42（n = 82）；第3组，得分42至53（n = 69）；第4组，得分大于53（n = 54）。采用Kaplan-Meier分析评估移植物和患者的生存情况，并采用Cox回归分析确定混杂因素的影响。四组的人口统计学特征相似。通过Kaplan-Meier和Cox回归生存分析，各组之间1年、2年和5年的移植物和患者生存率无显著差异。总之，SES不能预测肝移植后的移植物和患者生存情况。
