Gabbay E J, Adawadkar P D, Kapicak L, Pearce S, Wilson W D
Biochemistry. 1976 Jan 13;15(1):152-7. doi: 10.1021/bi00646a023.
Proton magnetic resonance studies (1H NMR) of the interaction of oligopeptide amides of defined sequence (and containing the amino acid, phenylalanine) with salmon sperm DNA are reported. The extent of upfield chemical shifts, deltasigma, and signal line broadening of the aromatic protons (in the presence of excess DNA) are found to depend on the primary sequence and stereochemistry of alpha carbons of the amino acids in the oligopeptide amides. The results obtained with 21 different di-, tri-, tetra-, penta- and hexapeptide amides are found to be consistent with a model whereby the peptide assumes a slightly modified single-stranded beta-sheet structure which is wrapped around the nucleic acid helix in a manner similar to that described by M. H. F. Wilkins (1956), Cold Spring Harbor Symp. Quant. Biol. 21, 75).
报道了对特定序列（含氨基酸苯丙氨酸）的寡肽酰胺与鲑鱼精DNA相互作用的质子磁共振研究（1H NMR）。发现芳香族质子的场移化学位移（deltasigma）程度以及信号线展宽（在过量DNA存在下）取决于寡肽酰胺中氨基酸α碳的一级序列和立体化学。用21种不同的二肽、三肽、四肽、五肽和六肽酰胺得到的结果与一种模型一致，即该肽呈现出一种略有修饰的单链β-折叠结构，它以类似于M. H. F. 威尔金斯（1956年，《冷泉港定量生物学研讨会》第21卷，第75页）所描述的方式缠绕在核酸螺旋周围。
