Strieter Robert M, Belperio John A, Keane Michael P
Department of Medicine, UCLA School of Medicine, Los Angeles, CA CA 90024-1922, USA.
Chest. 2002 Dec;122(6 Suppl):298S-301S. doi: 10.1378/chest.122.6_suppl.298s.
Angiogenesis, defined as the growth of new capillaries from preexisting vessels, is a pervasive biological phenomenon that is at the core of many physiologic and pathologic processes. An opposing balance of angiogenic and angiostatic factors regulates angiogenesis. Examples of physiologic processes that depend on angiogenesis include embryogenesis, wound repair, and the ovarian/menstrual cycle. In contrast, chronic inflammation associated with chronic fibroproliferative disorders as well as growth and metastasis of solid tumors are associated with aberrant angiogenesis. CXC chemokines comprise a unique cytokine family that contains members that exhibit on a structural/functional basis either angiogenic or angiostatic biological activity. In this review, we will discuss the role of CXC chemokines and angiogenesis in pulmonary fibrosis.
血管生成被定义为从已有的血管中生长出新的毛细血管，是一种普遍存在的生物学现象，是许多生理和病理过程的核心。血管生成因子和血管生成抑制因子之间的平衡调节着血管生成。依赖血管生成的生理过程包括胚胎发育、伤口修复和卵巢/月经周期。相比之下，与慢性纤维增生性疾病相关的慢性炎症以及实体瘤的生长和转移与异常血管生成有关。CXC趋化因子构成了一个独特的细胞因子家族，其成员在结构/功能基础上表现出血管生成或血管生成抑制生物活性。在本综述中，我们将讨论CXC趋化因子和血管生成在肺纤维化中的作用。
