Macara Ian G, Baldarelli Richard, Field Christine M, Glotzer Michael, Hayashi Yasuhide, Hsu Shu-Chan, Kennedy Mary B, Kinoshita Makoto, Longtine Mark, Low Claudia, Maltais Lois J, McKenzie Louise, Mitchison Timothy J, Nishikawa Toru, Noda Makoto, Petty Elizabeth M, Peifer Mark, Pringle John R, Robinson Phillip J, Roth Dagmar, Russell S E Hilary, Stuhlmann Heidi, Tanaka Manami, Tanaka Tomoo, Trimble William S, Ware Jerry, Zeleznik-Le Nancy J, Zieger Barbara
Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
Mol Biol Cell. 2002 Dec;13(12):4111-3. doi: 10.1091/mbc.e02-07-0438.
There are 10 known mammalian septin genes, some of which produce multiple splice variants. The current nomenclature for the genes and gene products is very confusing, with several different names having been given to the same gene product and distinct names given to splice variants of the same gene. Moreover, some names are based on those of yeast or Drosophila septins that are not the closest homologues. Therefore, we suggest that the mammalian septin field adopt a common nomenclature system, based on that adopted by the Mouse Genomic Nomenclature Committee and accepted by the Human Genome Organization Gene Nomenclature Committee. The human and mouse septin genes will be named SEPT1-SEPT10 and Sept1-Sept10, respectively. Splice variants will be designated by an underscore followed by a lowercase "v" and a number, e.g., SEPT4_v1.
已知有10个哺乳动物的septin基因，其中一些会产生多种剪接变体。目前这些基因和基因产物的命名非常混乱，同一基因产物有几个不同的名称，而同一基因的剪接变体也有不同的名称。此外，一些名称是基于酵母或果蝇的septin，而它们并非最相近的同源物。因此，我们建议哺乳动物septin领域采用一种通用的命名系统，该系统基于小鼠基因组命名委员会采用并被人类基因组组织基因命名委员会认可的系统。人类和小鼠的septin基因将分别命名为SEPT1 - SEPT10和Sept1 - Sept10。剪接变体将通过下划线后跟小写字母“v”和数字来指定，例如SEPT4_v1。
