Sun Jie, Zheng Min-Ying, Li Yu-Wei, Zhang Shi-Wu
Department of Pathology, Tianjin Union Medical Center, Tianjin 300121, China.
Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, China.
World J Gastrointest Oncol. 2020 Jun 15;12(6):619-631. doi: 10.4251/wjgo.v12.i6.619.
The treatment and prognosis of malignant tumors are closely related to the time when the tumors are diagnosed; the earlier the diagnosis of the tumor, the better the prognosis. However, most tumors are not detected in the early stages of screening and diagnosis. It is of great clinical significance to study the correlation between multiple pathogeneses of tumors and explore simple, safe, specific, and sensitive molecular indicators for early screening, diagnosis, and prognosis. The () gene has been found to be associated with a variety of human diseases, and it plays a role in the development of tumors. SEPT9 is a member of the conserved family of cytoskeletal GTPase, which consists of a P-loop-based GTP-binding domain flanked by a variable N-terminal region and a C-terminal region. SEPT9 is involved in many biological processes such as cytokinesis, polarization, vesicle trafficking, membrane reconstruction, deoxyribonucleic acid repair, cell migration, and apoptosis. Several studies have shown that SEPT9 may serve as a marker for early screening, diagnosis, and prognosis of some malignant tumors, and have the potential to become a new target for anti-cancer therapy. This article reviews the progress in research on the gene in early screening, diagnosis, and prognosis of tumors.
恶性肿瘤的治疗和预后与肿瘤的诊断时间密切相关；肿瘤诊断越早，预后越好。然而，大多数肿瘤在筛查和诊断的早期阶段未被发现。研究肿瘤多种发病机制之间的相关性，并探索用于早期筛查、诊断和预后的简单、安全、特异且敏感的分子指标具有重要的临床意义。已发现（）基因与多种人类疾病相关，且在肿瘤发生发展中起作用。SEPT9是细胞骨架GTP酶保守家族的成员，由一个基于P环的GTP结合结构域组成，两侧分别是可变的N端区域和C端区域。SEPT9参与许多生物学过程，如胞质分裂、极化、囊泡运输、膜重建、脱氧核糖核酸修复、细胞迁移和凋亡。多项研究表明，SEPT9可能作为某些恶性肿瘤早期筛查、诊断和预后的标志物，并有潜力成为抗癌治疗的新靶点。本文综述了该基因在肿瘤早期筛查、诊断和预后方面的研究进展。
