Sengpiel Frank, Kind Peter C
Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK.
Curr Biol. 2002 Dec 10;12(23):R818-26. doi: 10.1016/s0960-9822(02)01318-0.
Neuronal activity is important for both the initial formation and the subsequent refinement of anatomical and physiological features of the mammalian visual system. Here we examine recent evidence concerning the role that spontaneous activity plays in axonal segregation, both of retinogeniculate afferents into eye-specific layers and of geniculocortical afferents into ocular dominance bands. We also assess the role of activity in the generation and plasticity of orientation selectivity in the primary visual cortex. Finally, we review recent challenges to textbook views on how inputs representing the two eyes interact during the critical period of visual cortical plasticity.
神经元活动对于哺乳动物视觉系统解剖和生理特征的初始形成及后续精细化都很重要。在此，我们考察了有关自发活动在轴突分离中所起作用的最新证据，轴突分离既包括视网膜神经节细胞传入纤维在眼特异性层中的分离，也包括外侧膝状体核到皮层的传入纤维在眼优势带中的分离。我们还评估了活动在初级视觉皮层方向选择性的产生和可塑性方面的作用。最后，我们回顾了近期对教科书观点的挑战，这些观点涉及在视觉皮层可塑性关键期，代表双眼的输入是如何相互作用的。
