胃癌患者胃液中CA 19-9和CEA水平的预后意义

The prognostic significance of gastric juice CA 19-9 and CEA levels in gastric carcinoma patients.

作者信息

Duraker N, Naci Celik A, Gençler N

机构信息

Fifth Department of Surgery, SSK Okmeydani Training Hospital, Istanbul, Turkey.

出版信息

Eur J Surg Oncol. 2002 Dec;28(8):844-9. doi: 10.1053/ejso.2002.1295.

DOI:10.1053/ejso.2002.1295

PMID:12477476

Abstract

AIM

The usefulness of gastric juice CA 19-9 and carcinoembryonic antigen (CEA) levels in the diagnosis of gastric carcinoma is controversial. There is only one study related with their prognostic value. In this study the clinical significance of gastric juice CA 19-9 and CEA levels in patients with gastric carcinoma was investigated.

METHODS

Preoperative serum and gastric juice CA 19-9 and CEA concentrations were measured in 139 patients with gastric carcinoma, 54 patients with benign gastroduodenal disease and as the 'healthy' control group 46 patients with inguinal hernia and with no other pathology.

RESULTS

In all groups the mean gastric juice levels of CA 19-9 and CEA were significantly higher than the serum levels. The gastric juice CA 19-9 levels were not different between groups. Gastric juice CEA levels of the gastric carcinoma group were significantly higher than those of the benign gastroduodenal disease group (P=0.007) and had a tendency to increase when compared to those of the control group (P=0.064) whereas there was no significant difference between the benign gastroduodenal disease and the control group. The cut-off values of gastric juice CA 19-9 and CEA were 440U/ml and 320ng/ml and the positivity ratios of these markers in gastric carcinoma patients were 16.5 and 27.3%, respectively. There was no significant relationship between the histopathological features and the gastric juice CA 19-9 or CEA positivities. Neither univariate analysis nor the multivariate Cox proportional hazards model analysis showed prognostic value for gastric juice CA 19-9 and CEA positivities.

CONCLUSIONS

The gastric juice CA 19-9 and CEA levels have no diagnostic and prognostic significance in gastric carcinoma patients.

摘要

目的

胃液中癌胚抗原（CEA）和糖类抗原19-9（CA 19-9）水平在胃癌诊断中的作用存在争议。仅有一项研究涉及其预后价值。本研究旨在探讨胃癌患者胃液中CA 19-9和CEA水平的临床意义。

方法

对139例胃癌患者、54例胃十二指肠良性疾病患者以及46例腹股沟疝且无其他病变的“健康”对照组患者，术前测定血清及胃液中CA 19-9和CEA浓度。

结果

所有组中，CA 19-9和CEA的胃液平均水平均显著高于血清水平。各组间胃液CA 19-9水平无差异。胃癌组胃液CEA水平显著高于胃十二指肠良性疾病组（P = 0.007），与对照组相比有升高趋势（P = 0.064），而胃十二指肠良性疾病组与对照组之间无显著差异。胃液CA 19-9和CEA的临界值分别为440U/ml和320ng/ml，这些标志物在胃癌患者中的阳性率分别为16.5%和27.3%。组织病理学特征与胃液CA 19-9或CEA阳性之间无显著关系。单因素分析和多因素Cox比例风险模型分析均未显示胃液CA 19-9和CEA阳性具有预后价值。