Redd Alan J, Agellon Al B, Kearney Veronica A, Contreras Veronica A, Karafet Tatiana, Park Hwayong, de Knijff Peter, Butler John M, Hammer Michael F
Division of Biotechnology, University of Arizona, Biosciences West room 239, Tucson, AZ 85721, USA.
Forensic Sci Int. 2002 Dec 4;130(2-3):97-111. doi: 10.1016/s0379-0738(02)00347-x.
We identified and characterized 14 novel short-tandem-repeats (STRs) on the Y chromosome and typed them in two samples, a globally diverse panel of 73 cell lines, and 148 individuals from a European-American population. These Y-STRs include eight tetranucleotide repeats (DYS449, DYS453, DYS454, DYS455, DYS456, DYS458, DYS459, and DYS464), five pentanucleotide repeats (DYS446, DYS447, DYS450, DYS452, and DYS463), and one hexanucleotide repeat (DYS448). Sequence data were obtained to designate a repeat number nomenclature. The gene diversities of an additional 22 Y-STRs, including the most commonly used in forensic databases, were directly compared in the cell line DNAs. Six of the 10 most polymorphic markers include the newly identified Y-STRs. Furthermore, these novel Y-STRs greatly improved the resolution of paternal lineages, above the level obtained with commonly used Y-STRs, in the European-American population.
我们在Y染色体上鉴定并表征了14个新型短串联重复序列（STR），并在两个样本中对其进行分型，一个是包含73个细胞系的全球多样化样本库，另一个是来自欧美人群的148名个体。这些Y-STR包括8个四核苷酸重复序列（DYS449、DYS453、DYS454、DYS455、DYS456、DYS458、DYS459和DYS464）、5个五核苷酸重复序列（DYS446、DYS447、DYS450、DYS452和DYS463）以及1个六核苷酸重复序列（DYS448）。获取了序列数据以指定重复数命名法。在细胞系DNA中直接比较了另外22个Y-STR的基因多样性，其中包括法医数据库中最常用的Y-STR。10个多态性最高的标记中有6个包括新鉴定的Y-STR。此外，在欧美人群中，这些新型Y-STR大大提高了父系谱系分辨率，高于常用Y-STR所达到的水平。
