Beh Terence, Splinter William, Kim Jarmila
Department of Anaesthetics, Monash Medical Centre, Clayton, Victoria, Australia.
Can J Anaesth. 2002 Dec;49(10):1061-3. doi: 10.1007/BF03017903.
To investigate if 50% nitrous oxide reduces the pain during injection of propofol mixed with lidocaine in children.
Healthy children undergoing iv induction of general anesthesia for elective surgery were recruited into this prospective, randomized, double-blind study. None of the patients received any premedication except for eutectic mixture of local anesthetics cream. Before induction of anesthesia with propofol 1% mixed with lidocaine 0.05% (propofol dose 3 mg x kg(-1)), the treatment group received 50% N(2)O in O(2) and the control group received 100% oxygen. Pain due to propofol administration was rated with a four-point behavioural scale: none, mild, moderate or severe.
There were 28 subjects in the control group and 26 subjects in the treatment group. Demographic data were similar in both groups. The incidence of pain at induction was 4% after N(2)O and 36% in the control group, P < 0.01. No patients had severe pain. Most patients had mild pain. Three of the ten patients with pain in the control group had moderate pain. The number needed to treat was 3:1.
Nitrous oxide reduces pain during induction with propofol mixed with lidocaine in healthy children.
研究50%氧化亚氮是否能减轻儿童注射丙泊酚与利多卡因混合液时的疼痛。
将择期手术接受静脉全身麻醉诱导的健康儿童纳入这项前瞻性、随机、双盲研究。除局部麻醉剂共熔混合物乳膏外，所有患者均未接受任何术前用药。在用1%丙泊酚与0.05%利多卡因混合液（丙泊酚剂量3mg·kg⁻¹）进行麻醉诱导前，治疗组接受50%氧化亚氮与氧气混合气体，对照组接受100%氧气。通过四点行为量表对丙泊酚给药引起的疼痛进行评分：无、轻度、中度或重度。
对照组有28名受试者，治疗组有26名受试者。两组的人口统计学数据相似。氧化亚氮组诱导时疼痛发生率为4%，对照组为36%，P<0.01。无患者出现重度疼痛。大多数患者为轻度疼痛。对照组10名疼痛患者中有3名出现中度疼痛。治疗所需人数为3:1。
氧化亚氮可减轻健康儿童在丙泊酚与利多卡因混合液诱导麻醉时的疼痛。
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