Beyaz Serbülent Gökhan, Eman Ali
Department of Anaesthesiology, Sakarya University Medical School, Sakarya, Republic of Turkey.
J Anaesthesiol Clin Pharmacol. 2012 Jul;28(3):314-7. doi: 10.4103/0970-9185.98322.
Propofol emulsion in medium and long-chain triglycerides (MCT/LCT) has been reported to cause less injection pain than other propofol solutions in adult studies. The aim of this study was to compare the injection pain of two different propofol emulsions using two different pain scales on the pediatric population.
100 children scheduled for general anesthesia were divided into two groups. Patients were randomly assigned to receive propofol LCT or propofol MCT/LCT. Assessment and evaluation of the Ontario Children's Hospital Pain Scale (mCHEOPS) and the Wong-Baker Faces Scale (WBFS) were performed at the start of the injection until the patients lose consciousness.
There were no significant differences between groups in terms of demographic data. According to the mCHEOPS scale, the pain incidence of propofol LCT was 5%, whereas for propofol MCT/LCT it was 15% (P < 0.05). According to the WBFS Pain Scale, the pain incidence of propofol LCT was 17%, whereas for propofol MCT/LCT it was 21% (P > 0.05).
Propofol MCT/LCT does not decrease injection pain; contrary to the general assumption, it causes more pain than propofol LCT in children.
在成人研究中，中长链甘油三酯（MCT/LCT）丙泊酚乳剂据报道比其他丙泊酚溶液引起的注射疼痛更少。本研究的目的是在儿科人群中使用两种不同的疼痛量表比较两种不同丙泊酚乳剂的注射疼痛。
100例计划接受全身麻醉的儿童被分为两组。患者被随机分配接受丙泊酚LCT或丙泊酚MCT/LCT。在注射开始至患者失去意识期间，使用安大略儿童医院疼痛量表（mCHEOPS）和面部表情疼痛量表（WBFS）进行评估和评价。
两组在人口统计学数据方面无显著差异。根据mCHEOPS量表，丙泊酚LCT的疼痛发生率为5%，而丙泊酚MCT/LCT为15%（P<0.05）。根据WBFS疼痛量表，丙泊酚LCT的疼痛发生率为17%，而丙泊酚MCT/LCT为21%（P>0.05）。
丙泊酚MCT/LCT不会减轻注射疼痛；与一般假设相反，在儿童中它比丙泊酚LCT引起的疼痛更多。
